Mutated Genes, Pathways, Processes and protein Domains in tumours web application.

fisher test

A Fisher's exact test was then performed with the R multtest package to find pathways, processes or protein domains in which mutated genes were significantly enriched for, in each tumour type. Essentially, the Fisher's test measured the significance of the association between the mutated proteins in a given pathway and the mutated proteins in a given tumour type. For each tumour type, only the total set of genes that had been screened for mutations was taken into account as the background to avoid any bias in the results. All the tests were adjusted for multiple testing according to the Benjamini & Hochberg FDR-controlling procedure.